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 Zdravniški forum
> Dermatologija |
| vprašanje: extrakt |
| avtor: aleš |
datum: 06.07.2003 16:18 |
Spoštovani dr. Godić
Kaj je Ginkgo biloba extrakt in ali se res uporablja tudi pri dermatoloških boleznih?
(vitiligo, npr.)
Hvala |
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| | | odgovor: extrakt |
| avtor: asist. dr. Aleksandar GodiĂŚ, dr. med. |
datum: 07.07.2003 00:03 |
Spoštovani,
eni izmed bralk sem odgovoril o ginku in vitiligu, tako da Vam posredujem identični odgovor. Bralka je v podatkovni bazi Medline zasledila članek o ginku in vitiligu, ki Vam ga najprej posredujem, na koncu sledi komentar.
AG
Effectiveness of oral Ginkgo biloba in treating limited, slowly spreading vitiligo.
Parsad D, Pandhi R, Juneja A.
For effective treatment of vitiligo, it is as important to arrest the progression of the disease as it is to induce repigmentation. Recently, oxidative stress has been shown to play an important role in the pathogenesis of vitiligo. Ginkgo biloba extract has been shown to have antioxidant and immunomodulatory properties. In a double-blind placebo-controlled trial, we evaluated the efficacy of G. biloba extract in controlling the activity of the disease process in patients with limited and slow-spreading vitiligo and in inducing repigmentation of vitiliginous areas. Fifty-two patients were assigned to two treatment groups (A and B) in a double-blind fashion, but only 47 patients could be evaluated, because one patient in group A and four patients in group B withdrew for reasons unrelated to the study. Patients in group A were given G. biloba extract 40 mg three times daily whereas patients in group B received placebo in similar doses. A statistically significant cessation of active progression of depigmentation was noted in patients treated with G. biloba (P = 0.006). Marked to complete repigmentation was seen in 10 patients in group A, whereas only two patients in group B showed similar repigmentation. The G. biloba extract was well tolerated. G. biloba extract seems to be a simple, safe and fairly effective therapy for arresting the progression of the disease.
Komentar:
1. študija je bila izvedena strokovno pravilno.
2. vključenih je bilo premajhno št. bolnikov, pa še ti so bili selekcionirani (počasi napredujoči in omejeni vitiligo, torej bolezen v akutni fazi).
2. ekstrakt ginka učinkuje po principu, ki zaustavi napredovanje vitliga, do repigmentacije pa je prišlo pri 10 bolnikih, kar je statistično značilno, v primerjavi s preisovanci v kontrolni skupini.
3. omenja se samo eden možen mehaniem vitiliga, ki ga avtor opisuje kot oksidativni stres, čeprav se ve,. da je bolezen avtoimuna.
Strokovna literatura je polna podobnih objav, ki so sporadične, z vključenim premajhnim številom bolnikov, pa še ti so običajno (ne)namerno selekcionirani. Resna medicinska dognanja nastajajo tekom večih let, desetletij, na osnovi dolgoročnih znanstvenih študij, ko jih farmacevtska industrija na koncu udejani z novim zdravilom. Do takrat lahko berete o tem in onem, morda poskušate to in ono, rezultati zdravljenja pa kljub temu ne bodo presegli Vaših (in zdravnikovih) pričakovanj, kot jih poznamo pri sicerjšnjem, doktrinarnem, zdravljenju vitiliga.
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